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Saturday, July 25, 2020 | History

3 edition of therapeutic range of the mercurial diuretics. found in the catalog.

therapeutic range of the mercurial diuretics.

Charles Crane Roby

therapeutic range of the mercurial diuretics.

by Charles Crane Roby

  • 304 Want to read
  • 38 Currently reading

Published .
Written in English

    Subjects:
  • Diuretics, Mercurial -- Physiological effect.

  • Classifications
    LC ClassificationsRM377 .R63
    The Physical Object
    Paginationii, 12 l.
    Number of Pages12
    ID Numbers
    Open LibraryOL4233359M
    LC Control Number80513852

    Start studying Brunner Chapter Patients With Endocrine Disorders-Book content. Learn vocabulary, terms, and more with flashcards, games, and other study tools.   Several human fatalities have recently been reported for which the intravenous injection of a mercurial diuretic was believed to be the causative agent. 1 It therefore seemed desirable to make a comparison of toxicity of the mercurial diuretics by this route and to study the influence of the drugs commonly used in the treatment of heart disease on this by:

    Mercurial diuretic synonyms, Mercurial diuretic pronunciation, Mercurial diuretic translation, English dictionary definition of Mercurial diuretic. adj. Tending to increase the discharge of urine. n. A substance or drug that tends to increase the discharge of urine. di′uret′ically adv. These new insights have also led to a new understanding of how the currently used diuretics act. Just a few months ago, the Na+Cl- co-transporter, which is the target of thiazides, the Na+2CI-K+ co-transporter, which is the target of furosemide, and .

    This section numbering tied the content to a rigid structure and enforced the retention of defunct classifications (such as mercurial diuretics) and hindered the relocation of drugs where therapeutic use had altered. It also caused constraints between the BNF and BNF for Children, where drugs had different therapeutic uses in children. Summary: Dandelion extract may have promising diuretic effects, including an increase in urine production. Its raw greens can be used in salads, sauteed like kale or added to an herbal tea. 2. Cilantro (Coriander) Cilantro (also known as coriander) is a popular herb often used fresh or dried for flavor and spice in cooking.


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Therapeutic range of the mercurial diuretics by Charles Crane Roby Download PDF EPUB FB2

Mercurial diuretics cause diuresis by reducing the reabsorption sodium in the ascending loop of Henle, thus causing more water being delivered to the distal convoluted tubule. Unfortunately, earlier physicians misconstrued hallmark symptoms of mercury poisoning such as excessive salivation as signs of mercury's efficacy, including up until the.

VOGL A. The discovery of the organic mercurial diuretics. Am Heart J. Jun; 39 (6)– FRIEDMAN HL. Relationship between chemical structure and biological activity in mercurial compounds. Ann N Y Acad Sci. Apr 11; 65 (5)– Bartram EA.

A diuretic (/ ˌ d aɪ j ʊ ˈ r ɛ t ɪ k /) is any substance that promotes diuresis, the increased production of includes forced are several categories of diuretics. All diuretics increase the excretion of water from bodies, although each class does so in a distinct way.

Alternatively, an antidiuretic, such as vasopressin (antidiuretic hormone), is an agent or drug ATC code: C [Report of a case of unusual complications following therapeutic application of mercurial diuretics].

[Article in Bulgarian] ATANASOVA L, NISIMOV R. PMID: [PubMed - indexed for MEDLINE] MeSH Terms. Diuretics/adverse effects* Organomercury Compounds/adverse effects* Skin Diseases* : Atanasova L, Nisimov R. Lant A (b) Diuretics, clinical pharmacology and therapeutic use, part II.

Drugs – PubMed CrossRef Google Scholar Lawrence JR, Ansari AF, Elliot HL, Sumner DJ, Brunton GF, Whiting B, Whitesmith R () Kinetic and dynamic comparison of piretanide and by: 6. Therapeutic Indications And Uses Of Diuretics The obvious effect of diuretics is to diminish the quantity of liquid in the circulation.

it is true that the portion of the blood evacuated by them is chiefly the water ; but some of the saline matters, and no doubt also more or less of the organic constituents, escape; so that these medicines may.

THE DISCOVERY OF THE ORGANIC MERCURIAL DIURETICS ALFRED VOGL, M.D.* NEW YORK, N. IT WAS on October 7,that Johanna was admitted to the First Medical University Clinic in Vienna, the Wenckebach by: Diuretic, any drug that increases the flow of ics promote the removal from the body of excess water, salts, poisons, and accumulated metabolic products, such as serve to rid the body of excess fluid that accumulates in the tissues owing to various disease are many types of diuretics, but most act by decreasing the amount of fluid that is reabsorbed by.

mercurial diuretic: any one of several diuretic agents that contain mercury in an organic chemical form. The principal use for the drugs is in treating edema of cardiac origin, ascites associated with cirrhosis, or oliguria in the nephrotic stage of glomerulonephritis. Immediate fatal reactions have occurred, usually as a result of ventricular.

The safety of mercurial diuretics has been so accepted by the medical profession that the pendulum has swung from the position of utilizing the mercurial diuretics as a last resort to a position of unrestricted use as long as edema or symptoms Cited by: 6.

Flaxman, referring to the mercurial diuretics used in heart disease pointed out that cases of sudden death due to the use of these drugs and fatal mercurialism continue to be reported Boyds remark in his chapter on Necrosis of the Liver that the introduction of the newer diuretics, such as the organic mercury compounds in association with.

Monitoring the therapeutic levels of certain medications is often conducted when the patient is taking medications with a narrow therapeutic range where a slight imbalance could be critical. Drug monitoring includes drawing blood samples for peak and trough levels to determine if blood serum levels of a specific drug are at a therapeutic level.

Mercurial diuretics act primarily on active transport of sodium. The mechanism of action probably involves a firm attachment of mercury to a sulfhydryl group of a renal enzyme that helps to generate energy for sodium transport, or to a sodium carrier.

In either case, the transporting system fails. To date, no known enzyme or specific carrier substance has been Cited by:   1. Theophylline has been shown to increase the absorption of Mercurin and Salyrgan from the site of intramuscular injection in proportion to the amount present.

One mole equivalent produces complete absorption after 55 minutes. Succinimide, uracil, hydantoin, ammonium chloride and glycine have all been found to improve the absorption of Mercurin but Cited by: 3. But calomel had a cathartic effect so that it was replaced by organic mercurial compounds.

These diuretics were clearly toxic. After the discovery of the car­ bonic anhydrase, in the early s, and the introduction of sulfanilamide as a chemotherapeutic agent, it was observed that this drug was inhibiting carbonic anhydrase in vitro and Format: Hardcover.

This project is supported by the Canadian Institutes of Health Research (award #), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic is funded by Genome Alberta, Genome British Columbia, and Genome Canada.

Pharmacology and Clinical Use of Diuretics Katie Herndon, Pharm.D., BCPS Katie Herndon is not speaking on behalf of Pfizer, but solely as a medical professional with an expertise in pharmacotherapy.

Objectives • Review the mechanism of action, pharmacokinetics, and pharmacodynamics of diuretics • Contrast the pharmacology of differentFile Size: KB.

defunct classifications, such as mercurial diuretics, and hindered the relocation of drugs where therapeutic use had altered. It also caused constraints between the BNF and BNF for Children, where drugs had different therapeutic uses in children. —Appendix 4 – the content has been moved to individual drug monographs.

The introductory notes File Size: KB. The metabolic acidosis that CAIs induce reduces their diuretic effect in _____ days. Common side effects of CAIs are anorexia, nausea/vomitting, hematuria, photosensitivity, rash, drowsiness, paresthesias, urticaria, melena, blood dyscrasias.

Recently a communication 1 was published in The Journal attributing the sudden death of 3 patients with congestive heart failure to the intravenous injection of a mercurial diuretic.

The publication of this statement stimulated a review of the toxic manifestations and the fatalities that have been reported in connection with these widely used agents.

Diuretics increase urinary excretion of water and electrolytes and are used to relieve oedema associated with heart failure, nephrotic syndrome or hepatic cirrhosis. Some diuretics are used at lower doses to reduce raised blood pressure. Osmotic diuretics are mainly used to treat cerebral oedema, and also to lower raised intraocular Size: 74KB.Diuretics - Therapeutic uses.

All diuretics increase the urinary elimination of sodium. Diuretics of Henle loop and of the initial part of the distal tubule are hypokalemic.

Those of the second part of the distal tubule, antialdosterones, amiloride and triamterene, are hyperkalemic. All diuretics can be used for the treatment of arterial.action, monitoring parameters, and indications for use of diuretics in the pediatric population ().

Loop Diuretics Loop diuretics are the most potent of the available diuretics (4). These agents work by blocking the Na+ -K+ -2Cl- transporter in the ascending loop of Henle, inhibiting reabsorption of these ions.

Because reabsorption of File Size: KB.